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KMID : 0380620120440010076
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Korean Journal of Food Science and Technology
2012 Volume.44 No. 1 p.76 ~ p.81
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A Study on the Depigmenting Effect of Carthamus tinctorius Seed, Cyperus rotundus and Schizonepeta tenuifolia Extracts
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Hwang Eun-Young
Kim Dong-Hee
Hwang Ju-Young
Kim Hui-Jeong
Park Tae-Soon
Lee In-Seon
Son Jun-Ho
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Abstract
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The objective of the present study was to evaluate the skin depigmentation effect of the extracts of three herbs, Carthamus tinctorius seed, Cyperus rotundus and Schizonepeta tenuifolia. Their effects on tyrosinase and melanin synthesis inhibitory action were assessed. We found that the C. tinctorius seed ethanol extracts reduced the tyrosinase activity and melanin formation of B16F10 melanoma cells. The C. tinctorius seed suppressed the expression in microphthalmia associated transcription factor (MITF), tyrosinase, tyrosinase related protein 1 (TRP-1), and tyrosinase related protein 2 (TRP-2) in B16F10 melanoma cells. These results show that C. tinctorius seed inhibited melanogenesis on the B16F10 melanoma cell. The underlying mechanism of C. tinctorius seed whitening activity may be the inhibition of tyrisinase, MITF, tyrosinase, TRP-1, and TRP-2 expression. The results suggested that C. tinctorius seed has considerable potential as a natural functional ingredient with a depigmentation effect.
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KEYWORD
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Carthamus tinctorius seed, tyrosinase, B16F10 melanoma cell, melanin synthesis, depigmenting effect
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